Mechanical Deformation Mediated Transmembrane Transport.
Macromol Rapid Commun
; 41(2): e1900518, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31885137
ABSTRACT
Transmembrane transport is essential and plays critical roles for molecule exchange for cell survival. Methods capable of mimicking and regulating transmembrane transport have transformed the ability to create biosensors, separation membranes, and drug carriers. However, artificial channels have been largely restricted by their complicated chemical fabrication and inefficiency to dynamically manipulate the transport process. Here, a novel approach to regulate transmembrane transport is described by simply adjusting the mechanical deformation of liposomal bilayers which are covalently embedded in a crosslinked hydrogel network. This new approach is able to dynamically control transmembrane transport by stretching and loosening. The transmembrane diffusion of molecules can be switched on and off, and precisely tuned by varying strain. A potential of this method to programmably regulate cell growth is demonstrated by tuning external mechanical force. Given its unique characteristics, this method allows the development of innovative systems for controlled transmembrane transport of molecules.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Hidrogeles
/
Canales Iónicos
/
Liposomas
Límite:
Humans
Idioma:
En
Revista:
Macromol Rapid Commun
Año:
2020
Tipo del documento:
Article
País de afiliación:
China