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Systematic Review with Meta-Analysis: The Effects of Probiotics in Nonalcoholic Fatty Liver Disease.
Xiao, Meng-Wei; Lin, Shi-Xin; Shen, Zhao-Hua; Luo, Wei-Wei; Wang, Xiao-Yan.
Afiliación
  • Xiao MW; Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
  • Lin SX; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha 410013, China.
  • Shen ZH; Department of Gynecology and Obstetrics, Third Affiliated Hospital of Nanchang University, Nanchang 330000, China.
  • Luo WW; Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
  • Wang XY; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha 410013, China.
Gastroenterol Res Pract ; 2019: 1484598, 2019.
Article en En | MEDLINE | ID: mdl-31885541
BACKGROUND AND AIMS: Probiotics was considered as a potential therapy for nonalcoholic fatty liver disease (NAFLD) without approval and comprehensive assessment in recent years, which call for a meta-analysis. METHODS: We performed electronic and manual searches including English and Chinese databases published before April 2019, with the use of mesh term and free text of "nonalcoholic fatty liver disease" and "probiotics." Clinical trials evaluating the efficacy of probiotic therapy in NAFLD patients were included according to the eligibility criteria. With the use of random effects models, clinical outcomes were presented as weighted mean difference (WMD) with 95% confidence interval (CI), while heterogeneity and meta-regression were also assessed. RESULTS: 28 clinical trials enrolling 1555 criterion proven NAFLD patients with the use of probiotics from 4 to 28 weeks were included. Overall, probiotic therapy had beneficial effects on body mass index (WMD: -1.46, 95% CI: [-2.44, -0.48]), alanine aminotransferase (WMD: -13.40, 95% CI: [-17.03, -9.77]), aspartate transaminase (WMD: -13.54, 95% CI: [-17.86, -9.22]), gamma-glutamyl transpeptidase (WMD: -9.88, 95% CI: [-17.77, -1.99]), insulin (WMD: -1.32, 95% CI: [-2.43, -0.21]), homeostasis model assessment-insulin resistance (WMD: -0.42, 95% CI: [-0.73, -0.12]), and total cholesterol (WMD: -15.38, 95% CI: [-26.50, -4.25]), but not in fasting blood sugar, lipid profiles, or tumor necrosis factor-alpha. CONCLUSION: The systematic review and meta-analysis support that probiotics are superior to placebo in NAFLD patients and could be utilized as a common complementary therapeutic approach.

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Idioma: En Revista: Gastroenterol Res Pract Año: 2019 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Idioma: En Revista: Gastroenterol Res Pract Año: 2019 Tipo del documento: Article País de afiliación: China