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Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections.
Bergsten, Helena; Madsen, Martin Bruun; Bergey, Francois; Hyldegaard, Ole; Skrede, Steinar; Arnell, Per; Oppegaard, Oddvar; Itzek, Andreas; Perner, Anders; Svensson, Mattias; Norrby-Teglund, Anna.
Afiliación
  • Bergsten H; Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Huddinge, Stockholm, Sweden.
  • Madsen MB; Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Bergey F; LifeGlimmer GmbH, Berlin, Germany.
  • Hyldegaard O; Department of Anesthesia and Surgery, Hyperbaric Unit, Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
  • Skrede S; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Arnell P; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Oppegaard O; Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Itzek A; Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Perner A; Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Svensson M; Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Norrby-Teglund A; Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Clin Infect Dis ; 71(7): 1772-1775, 2020 10 23.
Article en En | MEDLINE | ID: mdl-31916575
ABSTRACT
Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Infecciones de los Tejidos Blandos / Fascitis Necrotizante Límite: Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Suecia
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Infecciones de los Tejidos Blandos / Fascitis Necrotizante Límite: Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Suecia