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Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan, Tavia; Lorente-Macías, Álvaro; Stogios, Peter J; Evdokimova, Elena; Hyde, Sabrina; Wellington, Melanie A; Liston, Sean; Iyer, Kali R; Puumala, Emily; Shekhar-Guturja, Tanvi; Robbins, Nicole; Savchenko, Alexei; Krysan, Damian J; Whitesell, Luke; Zuercher, William J; Cowen, Leah E.
Afiliación
  • Caplan T; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Lorente-Macías Á; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry Applied to Biomed
  • Stogios PJ; Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5G 1M1, Canada; Center for Structural Genomics of Infectious Diseases (CSGID), Toronto, ON, M5G 1M1, Canada.
  • Evdokimova E; Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5G 1M1, Canada; Center for Structural Genomics of Infectious Diseases (CSGID), Toronto, ON, M5G 1M1, Canada.
  • Hyde S; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Wellington MA; Departments of Pediatrics and Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Liston S; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Iyer KR; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Puumala E; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Shekhar-Guturja T; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Robbins N; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Savchenko A; Center for Structural Genomics of Infectious Diseases (CSGID), Toronto, ON, M5G 1M1, Canada; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 4N1, Canada.
  • Krysan DJ; Departments of Pediatrics and Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
  • Whitesell L; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada.
  • Zuercher WJ; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599,
  • Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1M1, Canada. Electronic address: leah.cowen@utoronto.ca.
Cell Chem Biol ; 27(3): 269-282.e5, 2020 03 19.
Article en En | MEDLINE | ID: mdl-31924499
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Proteínas Fúngicas / Farmacorresistencia Fúngica / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2020 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Candida albicans / Candidiasis / Proteínas Fúngicas / Farmacorresistencia Fúngica / Inhibidores de Proteínas Quinasas Límite: Animals / Humans Idioma: En Revista: Cell Chem Biol Año: 2020 Tipo del documento: Article País de afiliación: Canadá