Your browser doesn't support javascript.
loading
Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory.
Asrat, Seblewongel; Kaur, Navneet; Liu, Xia; Ben, Li-Hong; Kajimura, Daisuke; Murphy, Andrew J; Sleeman, Matthew A; Limnander, Andre; Orengo, Jamie M.
Afiliación
  • Asrat S; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Kaur N; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Liu X; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Ben LH; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Kajimura D; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Murphy AJ; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Sleeman MA; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA.
  • Limnander A; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA. andre.limnander@regeneron.com jamie.orengo@regeneron.com.
  • Orengo JM; Regeneron Pharmaceuticals, Tarrytown, New York, NY 10591, USA. andre.limnander@regeneron.com jamie.orengo@regeneron.com.
Sci Immunol ; 5(43)2020 01 10.
Article en En | MEDLINE | ID: mdl-31924685
Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the source of IgE serological memory remains controversial. We reexamined the mechanism of serological memory in allergy using a dual reporter system to track IgE+ plasma cells in mice. Short-term allergen exposure resulted in the generation of IgE+ plasma cells that resided mainly in secondary lymphoid organs and produced IgE that was unable to degranulate mast cells. In contrast, chronic allergen exposure led to the generation of long-lived IgE+ plasma cells that were primarily derived from sequential class switching of IgG1, accumulated in the bone marrow, and produced IgE capable of inducing anaphylaxis. IgE+ plasma cells were found in the bone marrow of human allergic, but not nonallergic donors, and allergen-specific IgE produced by these cells was able to induce mast cell degranulation when transferred to mice. These data demonstrate that long-lived IgE+ bone marrow plasma cells arise during chronic allergen exposure and establish serological memory in both mice and humans.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Plasmáticas / Inmunoglobulina E / Alérgenos / Pyroglyphidae / Memoria Inmunológica Límite: Animals / Humans Idioma: En Revista: Sci Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Plasmáticas / Inmunoglobulina E / Alérgenos / Pyroglyphidae / Memoria Inmunológica Límite: Animals / Humans Idioma: En Revista: Sci Immunol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos