[Multidisciplinary meetings determining the imputability of xenobiotics in causes of death: What contribution to pharmacovigilance data?] / Réunions pluridisciplinaires déterminant l'imputabilité des xénobiotiques dans les causes de la mort : quel apport aux données de pharmacovigilance ?
Therapie
; 75(5): 481-490, 2020.
Article
en Fr
| MEDLINE
| ID: mdl-31926667
ABSTRACT
PURPOSE:
In case of xenobiotics induced toxic deaths analyzed at the university hospital of Rennes, a multidisplinary team of forensic analysts, toxicologists, anatomopathologists and pharmacologists assess xenobiotics' contribution to the death.METHODS:
A death contribution score (SCRIM) is collectively established during meetings for each death involving xenobiotic drugs. Graded between 1 and 6, lower was this score, more certain was the imputability. Among deaths with the highest imputability, drug poisonings were isolated.RESULTS:
Analysis of 266 deaths presented at meetings over the period 2010-2017 highlight a lot of drug medicine poisonings (60%). The main classes implicated are opioid substitution treatments (24%) followed by anxiolytics (23%), antidepressants (16%), legal opioids (16%) and antipsychotics (14%). Analysis of these cases by Rennes regional pharmacovigilance center permits to obtain a qualitative signal by establishing a local overview of the main risk classes but also to highlight a specific signal, in particular for oxycodone and antihistamines.CONCLUSIONS:
This multidisciplinary approach shows that a majority of toxic deaths are attributed to drugs. Mortality attributed to oxycodone and antihistamines is a specific signal that should be closely monitored.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Xenobióticos
/
Farmacovigilancia
Tipo de estudio:
Etiology_studies
/
Qualitative_research
Límite:
Humans
Idioma:
Fr
Revista:
Therapie
Año:
2020
Tipo del documento:
Article