Single-molecule imaging reveals the oligomeric state of functional TNF&#945;-induced plasma membrane TNFR1 clusters in cells.

Karathanasis, Christos; Medler, Juliane; Fricke, Franziska; Smith, Sonja; Malkusch, Sebastian; Widera, Darius; Fulda, Simone; Wajant, Harald; van Wijk, Sjoerd J L; Dikic, Ivan; Heilemann, Mike

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells.

Karathanasis, Christos; Medler, Juliane; Fricke, Franziska; Smith, Sonja; Malkusch, Sebastian; Widera, Darius; Fulda, Simone; Wajant, Harald; van Wijk, Sjoerd J L; Dikic, Ivan; Heilemann, Mike.

Afiliación

Karathanasis C; Institute of Physical and Theoretical Chemistry, Goethe University, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Medler J; Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Würzburg, Auverahaus, Grombühlstrasse 12, 97080 Würzburg, Germany.
Fricke F; Institute of Physical and Theoretical Chemistry, Goethe University, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Smith S; Institute for Experimental Cancer Research in Paediatrics, Goethe University, Komturstrasse 3a, 60528 Frankfurt am Main, Germany.
Malkusch S; Institute of Physical and Theoretical Chemistry, Goethe University, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Widera D; Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, RG6 6UB Reading, UK.
Fulda S; Institute for Experimental Cancer Research in Paediatrics, Goethe University, Komturstrasse 3a, 60528 Frankfurt am Main, Germany.
Wajant H; German Cancer Consortium (DKTK), Heidelberg, Germany.
van Wijk SJL; German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Dikic I; Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Würzburg, Auverahaus, Grombühlstrasse 12, 97080 Würzburg, Germany.
Heilemann M; Institute for Experimental Cancer Research in Paediatrics, Goethe University, Komturstrasse 3a, 60528 Frankfurt am Main, Germany. s.wijk@kinderkrebsstiftung-frankfurt.de ivan.dikic@biochem2.de heilemann@chemie.uni-frankfurt.de.

Sci Signal ; 13(614)2020 01 14.

Article en En | MEDLINE | ID: mdl-31937565

Asunto(s)

Membrana Celular/efectos de los fármacos; Multimerización de Proteína; Receptores Tipo I de Factores de Necrosis Tumoral/metabolismo; Imagen Individual de Molécula/métodos; Factor de Necrosis Tumoral alfa/farmacología; Animales; Apoptosis/efectos de los fármacos; Membrana Celular/metabolismo; Células Cultivadas; Embrión de Mamíferos/citología; Fibroblastos/citología; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Células HeLa; Humanos; Ratones Noqueados; Ratones Transgénicos; Modelos Moleculares; Mutación; FN-kappa B/metabolismo; Unión Proteica; Transporte de Proteínas/efectos de los fármacos; Receptores Tipo I de Factores de Necrosis Tumoral/química; Receptores Tipo I de Factores de Necrosis Tumoral/genética; Transducción de Señal/efectos de los fármacos; Factor de Necrosis Tumoral alfa/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Membrana Celular / Factor de Necrosis Tumoral alfa / Receptores Tipo I de Factores de Necrosis Tumoral / Multimerización de Proteína / Imagen Individual de Molécula Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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