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Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio-Crosslinking.
Denk, Christoph; Wilkovitsch, Martin; Aneheim, Emma; Herth, Matthias M; Jensen, Holger; Lindegren, Sture; Mikula, Hannes.
Afiliación
  • Denk C; Institute of Applied Synthetic Chemistry, Vienna University of Technology (TU Wien), Getreidemarkt 9/163, 1060, Vienna, Austria.
  • Wilkovitsch M; Institute of Applied Synthetic Chemistry, Vienna University of Technology (TU Wien), Getreidemarkt 9/163, 1060, Vienna, Austria.
  • Aneheim E; Department of Radiation Physics, Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gula Stråket 2b, 41345, Gothenburg, Sweden.
  • Herth MM; Department of Drug Design and Pharmacology, University of Copenhagen, 2100, Copenhagen, Denmark.
  • Jensen H; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Lindegren S; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
  • Mikula H; Department of Radiation Physics, Institute for Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gula Stråket 2b, 41345, Gothenburg, Sweden.
Chempluschem ; 84(7): 774, 2019 07.
Article en En | MEDLINE | ID: mdl-31943997
ABSTRACT
Invited for this month's cover is the group of Dr. Hannes Mikula at Vienna University of Technology (TU Wien), Austria. The cover picture shows immobilized astatine-labeled reagents that have been sterically shielded with polyethylene chains by rapid bioorthogonal ligation leading to increased stability of the radiolabel in biological media. These multifunctional and bioorthogonal 211 At reagents can be efficiently prepared by rapid click assembly and simultaneous astatination. Read the full text of the article at 10.1002/cplu.201900114.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astato / Reactivos de Enlaces Cruzados / Química Clic Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Chempluschem Año: 2019 Tipo del documento: Article País de afiliación: Austria
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Astato / Reactivos de Enlaces Cruzados / Química Clic Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Chempluschem Año: 2019 Tipo del documento: Article País de afiliación: Austria