Malignancy predicts outcome of Takotsubo syndrome: a systematic review and meta-analysis.
Heart Fail Rev
; 25(3): 513-522, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-31956929
ABSTRACT
Over the recent years, studies have emerged reporting on a strong relationship between the occurrence of malignancy and Takotsubo syndrome. The aim of this systematic review and meta-analysis is to evaluate the predictive value of malignancy for prognosis of Takotsubo syndrome patients. PubMed, EMBASE, Cochrane Library, Web of science, and Scopus were searched until 4 September 2019 for articles concerning association of malignancy with the prognosis of Takotsubo syndrome. A total of ten studies were finally included in this meta-analysis, demonstrating that malignancy was associated with higher mortality in Takotsubo syndrome patients (RR 2.23, 95% CI 1.64-3.03, Z = 5.10, P < 0.00001). Differences between individual studies were significant, which were due to sample size and percentage of malignant patients in each study indicated by meta-regression and then verified by sensitivity analysis. Subgroup analysis demonstrated that the predictive value of malignancy in mortality risk of Takotsubo syndrome patients was significant for both in-hospital death (RR 2.26, 95% CI 1.34-3.82, Z = 3.06, P = 0.002) and follow-up death (RR 2.04, 95% CI 1.63-2.55, Z = 6.21, P < 0.00001). Further analysis of other in-hospital outcomes demonstrated increased incidence of mechanical ventilation in cancer patients. Our meta-analysis suggested that malignancy plays a significant role in predicting the mortality of Takotsubo syndrome patients whether in the short term or long term.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cardiomiopatía de Takotsubo
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Neoplasias
Tipo de estudio:
Incidence_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Heart Fail Rev
Asunto de la revista:
CARDIOLOGIA
Año:
2020
Tipo del documento:
Article