A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.

Chen, Siming; Jiao, Lianying; Liu, Xiuli; Yang, Xin; Liu, Xin

Chen, Siming; Jiao, Lianying; Liu, Xiuli; Yang, Xin; Liu, Xin.

Afiliación

Chen S; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Jiao L; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Liu X; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Yang X; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Liu X; Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Research, Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: xin.liu

Mol Cell ; 77(6): 1265-1278.e7, 2020 03 19.

Article en En | MEDLINE | ID: mdl-31959557

Asunto(s)

Cromatina/metabolismo; Islas de CpG; Metilación de ADN; Histonas/metabolismo; Complejo Represivo Polycomb 2/química; Multimerización de Proteína; Animales; Diferenciación Celular; Cromatina/genética; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Histonas/genética; Humanos; Ratones; Ratones Noqueados; Células Madre Embrionarias de Ratones/citología; Células Madre Embrionarias de Ratones/metabolismo; Proteínas de Neoplasias; Complejo Represivo Polycomb 2/genética; Complejo Represivo Polycomb 2/metabolismo; Complejo Represivo Polycomb 2/fisiología; Conformación Proteica; Proteína 4 de Unión a Retinoblastoma/genética; Proteína 4 de Unión a Retinoblastoma/metabolismo; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

CpG island (CGI); chromatin; crystal structure; epigenetics; gene silencing; histone methylation; polycomb repressive complex 2 (PRC2); polycomb-like (PCL); protein dimerization; structural biology

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cromatina / Histonas / Islas de CpG / Metilación de ADN / Multimerización de Proteína / Complejo Represivo Polycomb 2 Límite: Animals / Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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