Your browser doesn't support javascript.
loading
Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder.
Boldrini, Vinícius O; Brandão, Carlos Otávio; Pimentel, Maria Lucia V; Vidal, Aline; Mansur, Letícia F; Quintiliano, Raphael P S; Santos, Leonilda M B; Farias, Alessandro S.
Afiliación
  • Boldrini VO; Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National
  • Brandão CO; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Rio de Janeiro, Brazil; Department of Neurology, University of Campi
  • Pimentel MLV; Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Vidal A; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Mansur LF; Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Quintiliano RPS; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.
  • Santos LMB; Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National
  • Farias AS; Autoimmune Research Lab, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; Neuroimmunology Unit, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil; National
J Neuroimmunol ; 340: 577148, 2020 03 15.
Article en En | MEDLINE | ID: mdl-31986375
ABSTRACT
Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T / Neuromielitis Óptica / Citotoxicidad Inmunológica Límite: Female / Humans / Middle aged Idioma: En Revista: J Neuroimmunol Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T / Neuromielitis Óptica / Citotoxicidad Inmunológica Límite: Female / Humans / Middle aged Idioma: En Revista: J Neuroimmunol Año: 2020 Tipo del documento: Article