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Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.
Kay, Kenneth; Chung, Jason E; Sosa, Marielena; Schor, Jonathan S; Karlsson, Mattias P; Larkin, Margaret C; Liu, Daniel F; Frank, Loren M.
Afiliación
  • Kay K; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: kk3291@columbia.edu.
  • Chung JE; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Sosa M; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Schor JS; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Karlsson MP; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Larkin MC; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Liu DF; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA.
  • Frank LM; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisc
Cell ; 180(3): 552-567.e25, 2020 02 06.
Article en En | MEDLINE | ID: mdl-32004462
ABSTRACT
Cognitive faculties such as imagination, planning, and decision-making entail the ability to represent hypothetical experience. Crucially, animal behavior in natural settings implies that the brain can represent hypothetical future experience not only quickly but also constantly over time, as external events continually unfold. To determine how this is possible, we recorded neural activity in the hippocampus of rats navigating a maze with multiple spatial paths. We found neural activity encoding two possible future scenarios (two upcoming maze paths) in constant alternation at 8 Hz one scenario per ∼125-ms cycle. Further, we found that the underlying dynamics of cycling (both inter- and intra-cycle dynamics) generalized across qualitatively different representational correlates (location and direction). Notably, cycling occurred across moving behaviors, including during running. These findings identify a general dynamic process capable of quickly and continually representing hypothetical experience, including that of multiple possible futures.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Conducta Animal / Cognición / Toma de Decisiones / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Conducta Animal / Cognición / Toma de Decisiones / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article