Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.
Cell
; 180(3): 552-567.e25, 2020 02 06.
Article
en En
| MEDLINE
| ID: mdl-32004462
ABSTRACT
Cognitive faculties such as imagination, planning, and decision-making entail the ability to represent hypothetical experience. Crucially, animal behavior in natural settings implies that the brain can represent hypothetical future experience not only quickly but also constantly over time, as external events continually unfold. To determine how this is possible, we recorded neural activity in the hippocampus of rats navigating a maze with multiple spatial paths. We found neural activity encoding two possible future scenarios (two upcoming maze paths) in constant alternation at 8 Hz one scenario per â¼125-ms cycle. Further, we found that the underlying dynamics of cycling (both inter- and intra-cycle dynamics) generalized across qualitatively different representational correlates (location and direction). Notably, cycling occurred across moving behaviors, including during running. These findings identify a general dynamic process capable of quickly and continually representing hypothetical experience, including that of multiple possible futures.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Cognición
/
Toma de Decisiones
/
Hipocampo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell
Año:
2020
Tipo del documento:
Article