Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.

Perazzolo, Simone; Shireman, Laura M; McConnachie, Lisa A; Koehn, Josefin; Kinman, Loren; Lee, Wonsok; Lane, Sarah; Collier, Ann C; Shen, Danny D; Ho, Rodney J Y

Perazzolo, Simone; Shireman, Laura M; McConnachie, Lisa A; Koehn, Josefin; Kinman, Loren; Lee, Wonsok; Lane, Sarah; Collier, Ann C; Shen, Danny D; Ho, Rodney J Y.

Afiliación

Perazzolo S; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Shireman LM; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
McConnachie LA; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Koehn J; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Kinman L; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Lee W; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Lane S; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Collier AC; Department of Medicine, University of Washington, Seattle, Washington 98195; Center for AIDS Research, University of Washington, Seattle, Washington 98195.
Shen DD; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195.
Ho RJY; Department of Pharmaceutics and Targeted and Long-Acting Drug Combination Anti-Retroviral Therapeutic (TLC-ART) Program, University of Washington, Seattle, Washington 98195; Department of Bioengineering, University of Washington, Seattle, Washington 98195. Electronic address: rodneyho@uw.edu.

J Pharm Sci ; 109(5): 1789-1801, 2020 05.

Article en En | MEDLINE | ID: mdl-32006525

Asunto(s)

Fármacos Anti-VIH; Infecciones por VIH; Preparaciones Farmacéuticas; Animales; Fármacos Anti-VIH/uso terapéutico; Combinación de Medicamentos; Infecciones por VIH/tratamiento farmacológico; Lopinavir; Ritonavir

Palabras clave

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) (PubChem CID: 94190); 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (DSPE-mPEG(2000)) (PubChem CID: 406952); AIDS; HIV; Lopinavir (PubChem CID: 92727); drug-combination; lipid nanoparticle(s) (LNP); long-acting; preclinical pharmacokinetics; ritonavir (PubChem CID: 392622); targeted drug delivery; targeted therapy; tenofovir (PubChem CID: 464205)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Infecciones por VIH / Fármacos Anti-VIH Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Pharm Sci Año: 2020 Tipo del documento: Article

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