Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.
J Pharm Sci
; 109(5): 1789-1801, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32006525
Palabras clave
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) (PubChem CID: 94190); 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt) (DSPE-mPEG(2000)) (PubChem CID: 406952); AIDS; HIV; Lopinavir (PubChem CID: 92727); drug-combination; lipid nanoparticle(s) (LNP); long-acting; preclinical pharmacokinetics; ritonavir (PubChem CID: 392622); targeted drug delivery; targeted therapy; tenofovir (PubChem CID: 464205)
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Infecciones por VIH
/
Fármacos Anti-VIH
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Pharm Sci
Año:
2020
Tipo del documento:
Article