Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology.
Diabetologia
; 63(5): 977-986, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32016567
ABSTRACT
AIMS/HYPOTHESIS:
Type 2 diabetes is associated with cognitive impairments, but it is unclear whether common genetic factors influence both type 2 diabetes risk and cognition.METHODS:
Using data from 1892 Mexican-American individuals from extended pedigrees, including 402 with type 2 diabetes, we examined possible pleiotropy between type 2 diabetes and cognitive functioning, as measured by a comprehensive neuropsychological test battery.RESULTS:
Negative phenotypic correlations (ρp) were observed between type 2 diabetes and measures of attention (Continuous Performance Test [CPT d'] ρp = -0.143, p = 0.001), verbal memory (California Verbal Learning Test [CVLT] recall ρp = -0.111, p = 0.004) and face memory (Penn Face Memory Test [PFMT] ρp = -0.127, p = 0.002; PFMT Delayed ρp = -0.148, p = 2 × 10-4), replicating findings of cognitive impairment in type 2 diabetes. Negative genetic correlations (ρg) were also observed between type 2 diabetes and measures of attention (CPT d' ρg = -0.401, p = 0.001), working memory (digit span backward test ρg = -0.380, p = 0.005), and face memory (PFMT ρg = -0.476, p = 2 × 10-4; PFMT Delayed ρg = -0.376, p = 0.005), suggesting that the same genetic factors underlying risk for type 2 diabetes also influence poor cognitive performance in these domains. Performance in these domains was also associated with type 2 diabetes risk using an endophenotype ranking value approach. Specifically, on measures of attention (CPT d' ß = -0.219, p = 0.005), working memory (digit span backward ß = -0.326, p = 0.035), and face memory (PFMT ß = -0.171, p = 0.023; PFMT Delayed ß = -0.215, p = 0.005), individuals with type 2 diabetes showed the lowest performance, while unaffected/unrelated individuals showed the highest performance, and those related to an individual with type 2 diabetes performed at an intermediate level. CONCLUSIONS/INTERPRETATION:
These findings suggest that cognitive impairment may be a useful endophenotype of type 2 diabetes and, therefore, help to elucidate the pathophysiological underpinnings of this chronic disease. DATAAVAILABILITY:
The data analysed in this study is available in dbGaP www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001215.v2.p2.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus Tipo 2
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Diabetologia
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos