The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1.

Ullah, Kifayat; Chen, Suping; Lu, Jiaqi; Wang, Xiaohui; Liu, Qing; Zhang, Yang; Long, Yaqiu; Hu, Zhanhong; Xu, Guoqiang

Ullah, Kifayat; Chen, Suping; Lu, Jiaqi; Wang, Xiaohui; Liu, Qing; Zhang, Yang; Long, Yaqiu; Hu, Zhanhong; Xu, Guoqiang.

Afiliación

Ullah K; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Chen S; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Lu J; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Wang X; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Liu Q; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Zhang Y; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Long Y; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China.
Hu Z; Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China sdfeyhzh@163.com.
Xu G; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, 199 Ren'ai Road, Suzhou, Jiangsu 215123, China gux2002@suda.edu.cn.

J Biol Chem ; 295(14): 4696-4708, 2020 04 03.

Article en En | MEDLINE | ID: mdl-32041778

Asunto(s)

Factores de Transcripción ARNTL/metabolismo; Senescencia Celular; Ubiquitina-Proteína Ligasas/metabolismo; Factores de Transcripción ARNTL/antagonistas & inhibidores; Factores de Transcripción ARNTL/genética; Núcleo Celular/metabolismo; Senescencia Celular/efectos de los fármacos; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Cicloheximida/farmacología; Regulación hacia Abajo; Células HEK293; Humanos; Peróxido de Hidrógeno/farmacología; Mutagénesis Sitio-Dirigida; Complejo de la Endopetidasa Proteasomal/química; Complejo de la Endopetidasa Proteasomal/metabolismo; Unión Proteica; Proteolisis/efectos de los fármacos; Interferencia de ARN; ARN Interferente Pequeño; Proteína p53 Supresora de Tumor/metabolismo; Ubiquitina-Proteína Ligasas/antagonistas & inhibidores; Ubiquitina-Proteína Ligasas/genética; Ubiquitinación

Palabras clave

E3 ubiquitin ligase; STIP1 homology and U-box-containing protein 1 (STUB1); brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3); cell cycle regulation; circadian clock; hydrogen peroxide; proteasome; protein degradation; senescence; ubiquitylation (ubiquitination)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Senescencia Celular / Ubiquitina-Proteína Ligasas / Factores de Transcripción ARNTL Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: China

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