Distinct decrease in peripheral lymphocytes in EBER-positive cases of MTX-LPD.
Mod Rheumatol
; 31(1): 88-93, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-32075469
ABSTRACT
OBJECTIVES:
To determine the clinical characteristics of methotrexate-associated lymphoproliferative disorder (MTX-LPD).METHODS:
In this study, 12 RA patients who developed MTX-LPD were assessed. The peripheral blood lymphocyte (PBL) count at the onset of MTX-LPD was compared to that 6 months before the onset, in Epstein-Barr virus-encoded RNA (EBER)-positive and -negative subgroups. We examined the change in the PBL count after MTX withdrawal. In patients with relapsed LPD, changes in the PBL count before relapse were also examined.RESULTS:
Regression of LPD after MTX withdrawal was noted in eight patients. In these patients, the PBL count was decreased at the onset of MTX-LPD compared to 6 months before the onset; the decrease was significantly more prominent in EBER-positive patients. In cases of spontaneous regression of LPD, the PBL count recovered quickly after MTX withdrawal. Four of eight patients showed a recurrence of LPD after they improved following MTX withdrawal. These patients also exhibited a decreased PBL count at recurrence compared to 6 months before recurrence.CONCLUSION:
A decrease in the PBL count might be involved in the pathogenesis of MTX-LPD, especially in EBER-positive cases and in patients with LPD relapse after MTX withdrawal following initial improvement.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Linfocitos
/
Metotrexato
/
Recuento de Linfocitos
/
Trastornos Linfoproliferativos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Mod Rheumatol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón