Mechanisms underlying immobilization-induced muscle pain in rats.
Muscle Nerve
; 61(5): 662-670, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-32083755
ABSTRACT
INTRODUCTION:
We investigated the mechanisms underlying immobilization-induced muscle pain in rats.METHODS:
In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin-1ß (IL-1ß) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.RESULTS:
Immobilization resulted in a decrease in PPT and increases in NGF level, C-fiber density, M1 macrophage number, and IL-1ß mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.DISCUSSION:
NGF upregulation may be a major contributor to immobilization-induced muscle pain. The increases in C-fiber density, M1 macrophage number, and IL-1ß mRNA expression may be related to immobilization-induced muscle pain.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
ARN Mensajero
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Umbral del Dolor
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Músculo Esquelético
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Factor de Crecimiento Nervioso
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Interleucina-1beta
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Hiperalgesia
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Inmovilización
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Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón