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Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.
De Paula, Viviane S; Jude, Kevin M; Nerli, Santrupti; Glassman, Caleb R; Garcia, K Christopher; Sgourakis, Nikolaos G.
Afiliación
  • De Paula VS; Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064.
  • Jude KM; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305.
  • Nerli S; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305.
  • Glassman CR; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.
  • Garcia KC; Department of Computer Science, University of California, Santa Cruz, CA 95064.
  • Sgourakis NG; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305.
Proc Natl Acad Sci U S A ; 117(13): 7183-7192, 2020 03 31.
Article en En | MEDLINE | ID: mdl-32184322
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Interleucina-2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Interleucina-2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article