FVIII activity following FVIII protein infusion or FVIII gene transfer predicts the bleeding risk in hemophilia A rats.

Lövgren, Karin M; Larsen, Malte S; Zintner, Shannon M; Small, Juliana C; Kjelgaard-Hansen, Mads; Häger, Mattias; Petersen, Maj; Wiinberg, Bo; Margaritis, Paris

Lövgren, Karin M; Larsen, Malte S; Zintner, Shannon M; Small, Juliana C; Kjelgaard-Hansen, Mads; Häger, Mattias; Petersen, Maj; Wiinberg, Bo; Margaritis, Paris.

Afiliación

Lövgren KM; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Larsen MS; Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Zintner SM; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Small JC; Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kjelgaard-Hansen M; Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Häger M; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Petersen M; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Wiinberg B; Global Drug Discovery, Novo Nordisk A/S, Maaloev, Denmark.
Margaritis P; R&D Strategy, Novo Nordisk A/S, Bagsvaerd, Denmark.

J Thromb Haemost ; 18(7): 1586-1597, 2020 07.

Article en En | MEDLINE | ID: mdl-32196903

Asunto(s)

Hemofilia A; Hemostáticos; Animales; Factor VIII/genética; Terapia Genética; Hemofilia A/genética; Hemofilia A/terapia; Hemorragia/prevención & control; Humanos; Ratas

Palabras clave

animal; genetic therapy; hemophilia A; models; risk; therapeutics

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Hemostáticos / Hemofilia A Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca

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