Single-stage repair of contaminated hernias using a novel antibiotic-impregnated biologic porcine submucosa tissue matrix.
BMC Surg
; 20(1): 58, 2020 Mar 30.
Article
en En
| MEDLINE
| ID: mdl-32228664
ABSTRACT
BACKGROUND:
Single-stage repair of incisional hernias in contaminated fields has a high rate of surgical site infection (30-42%) when biologic grafts are used for repair. In an attempt to decrease this risk, a novel graft incorporating gentamicin into a biologic extracellular matrix derived from porcine small intestine submucosa was developed.METHODS:
This prospective, multicenter, single-arm observational study was designed to determine the incidence of surgical site infection following implantation of the device into surgical fields characterized as CDC Class II, III, or IV.RESULTS:
Twenty-four patients were enrolled, with 42% contaminated and 25% dirty surgical fields. After 12 months, 5 patients experienced 6 surgical site infections (21%) with infection involving the graft in 2 patients (8%). No grafts were explanted.CONCLUSIONS:
The incorporation of gentamicin into a porcine-derived biologic graft can be achieved with no noted gentamicin toxicity and a low rate of device infection for patients undergoing single-stage repair of ventral hernia in contaminated settings. TRIAL REGISTRATION The study was registered March 27, 2015 at www.clinicaltrials.gov as NCT02401334.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Infección de la Herida Quirúrgica
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Herniorrafia
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Hernia Incisional
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Hernia Ventral
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Antibacterianos
Tipo de estudio:
Clinical_trials
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Incidence_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
BMC Surg
Año:
2020
Tipo del documento:
Article
País de afiliación:
Canadá