Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Satheeshkumar, Rajendran; Zhu, Rui; Feng, Bo; Huang, Chao; Gao, Ya; Gao, Li-Xin; Shen, Chao; Hou, Ting-Jun; Xu, Lei; Li, Jia; Zhu, Yun-Long; Zhou, Yu-Bo; Wang, Wen-Long

Satheeshkumar, Rajendran; Zhu, Rui; Feng, Bo; Huang, Chao; Gao, Ya; Gao, Li-Xin; Shen, Chao; Hou, Ting-Jun; Xu, Lei; Li, Jia; Zhu, Yun-Long; Zhou, Yu-Bo; Wang, Wen-Long.

Afiliación

Satheeshkumar R; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.
Zhu R; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.
Feng B; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.
Huang C; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.
Gao Y; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China.
Gao LX; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Shen C; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Hou TJ; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Xu L; Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China.
Li J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhu YL; The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi 214002, China. Electronic address: sequoia113847@163.com.
Zhou YB; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: ybzhou@simm.ac.cn.
Wang WL; School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China. Electronic address: wwenlong2011@163.com.

Bioorg Med Chem Lett ; 30(11): 127170, 2020 06 01.

Article en En | MEDLINE | ID: mdl-32273218

Asunto(s)

Amidas/química; Inhibidores Enzimáticos/síntesis química; Compuestos Heterocíclicos/química; Proteína Tirosina Fosfatasa no Receptora Tipo 11/antagonistas & inhibidores; Amidas/metabolismo; Sitios de Unión; Inhibidores Enzimáticos/metabolismo; Humanos; Cinética; Simulación del Acoplamiento Molecular; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Proteína Tirosina Fosfatasa no Receptora Tipo 11/metabolismo; Relación Estructura-Actividad; Dominios Homologos src

Palabras clave

Heterocyclic bis-aryl amides; Inhibitors; PTP1B; SHP2; Structure-activity relationships (SAR)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Amidas / Compuestos Heterocíclicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China

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