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Young Adults With Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study.
Hamann, Steffen; Malmqvist, Lasse; Wegener, Marianne; Fard, Masoud Aghsaei; Biousse, Valérie; Bursztyn, Lulu; Citirak, Gülsenay; Costello, Fiona; Crum, Alison V; Digre, Kathleen; Fraser, J Alexander; Huna-Baron, Ruth; Katz, Bradley; Lawlor, Mitchell; Newman, Nancy J; Peragallo, Jason H; Petzold, Axel; Sibony, Patrick A; Subramanian, Prem S; Warner, Judith E A; Wong, Sui H; Fraser, Clare L.
Afiliación
  • Hamann S; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: steffen.hamann@regionh.dk.
  • Malmqvist L; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Wegener M; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Fard MA; Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
  • Biousse V; Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
  • Bursztyn L; Department of Ophthalmology, Western University, London, Ontario, Canada.
  • Citirak G; Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Costello F; Departments of Clinical Neurosciences and Surgery, University of Calgary, Canada.
  • Crum AV; Department of Ophthalmology and Visual Sciences, Department of Neurology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  • Digre K; Department of Ophthalmology and Visual Sciences, Department of Neurology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  • Fraser JA; Department of Ophthalmology, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.
  • Huna-Baron R; Goldschleger Eye Institute, Sheba Medical Center, el HaShomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
  • Katz B; Department of Ophthalmology and Visual Sciences, Department of Neurology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  • Lawlor M; Save Sight Institute Faculty of Health and Medicine, The University of Sydney, Sydney, New South Wales, Australia.
  • Newman NJ; Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Peragallo JH; Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Petzold A; Moorfields Eye Hospital, National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College of London, London, United Kingdom; Neuro-Ophthalmology Expertise Centre, VU University Medical Center, Amsterdam, the Netherlands.
  • Sibony PA; Department of Ophthalmology, State University of New York at Stony Brook, Stony Brook, New York, USA.
  • Subramanian PS; Departments of Ophthalmology, Neurology, and Neurosurgery, Sue Anschutz-Rodgers UC Health Eye Center, University of Colorado School of Medicine, Denver, Colorado, USA.
  • Warner JEA; Department of Ophthalmology and Visual Sciences, Department of Neurology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  • Wong SH; Department of Neuro-Ophthalmology, Moorfields Eye Hospital, London, United Kingdom.
  • Fraser CL; Save Sight Institute Faculty of Health and Medicine, The University of Sydney, Sydney, New South Wales, Australia.
Am J Ophthalmol ; 217: 174-181, 2020 09.
Article en En | MEDLINE | ID: mdl-32298654
PURPOSE: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION. DESIGN: Retrospective, cross-sectional multicenter study. METHODS: All patients with NA-AION 50 years old or younger, seen in neuro-ophthalmology clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, and March 31, 2019, were identified. Patients were included if ODD were diagnosed by any method, or if ODD were excluded by enhanced-depth imaging optical coherence tomography (EDI-OCT) using ODDS Consortium guidelines. NA-AION eyes with ODD were termed "ODD-AION"; those without were termed "NODD-AION". RESULTS: A total of 65 patients (127 eyes) with NA-AION were included (mean 41 years old). Of the 74 eyes with NA-AION, 51% had ODD-AION, whereas 43% of fellow eyes without NA-AION had ODD (P = .36). No significant differences were found between ODD-AION and NODD-AION eyes in terms of Snellen best-corrected VA or perimetric mean deviation. According to EDI-OCT results, 28% of eyes with NODD-AION had peripapillary hyperreflective ovoid mass-like structures (PHOMS); 7% had hyperreflective lines, whereas 54% with ODD-AION had PHOMS; and 66% had hyperreflective lines (P = .006 and P < .001, respectively). CONCLUSIONS: Most of these young NA-AION patients had ODD. This indicates that ODD may be an independent risk factor for the development of NA-AION, at least in younger patients. This study suggests ODD-AION be recognized as a novel diagnosis.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Disco Óptico / Angiografía con Fluoresceína / Agudeza Visual / Drusas del Disco Óptico / Neuropatía Óptica Isquémica / Tomografía de Coherencia Óptica Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Ophthalmol Año: 2020 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Disco Óptico / Angiografía con Fluoresceína / Agudeza Visual / Drusas del Disco Óptico / Neuropatía Óptica Isquémica / Tomografía de Coherencia Óptica Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Ophthalmol Año: 2020 Tipo del documento: Article