Liquid chromatography-high resolution mass spectrometric method for the quantification of monomethyl auristatin E (MMAE) and its preclinical pharmacokinetics.

Lee, Byeong Ill; Park, Min-Ho; Choi, Jangmi; Shin, Seok-Ho; Byeon, Jin-Ju; Park, Yuri; Shin, Young G

Lee, Byeong Ill; Park, Min-Ho; Choi, Jangmi; Shin, Seok-Ho; Byeon, Jin-Ju; Park, Yuri; Shin, Young G.

Afiliación

Lee BI; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Park MH; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Choi J; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Shin SH; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Byeon JJ; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Park Y; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Shin YG; College of Pharmacy, Chungnam National University, Daejeon, South Korea.

Biomed Chromatogr ; 34(8): e4855, 2020 Aug.

Article en En | MEDLINE | ID: mdl-32304111

Asunto(s)

Cromatografía Liquida/métodos; Espectrometría de Masas/métodos; Oligopéptidos/sangre; Oligopéptidos/farmacocinética; Animales; Modelos Animales de Enfermedad; Inmunoconjugados; Modelos Lineales; Masculino; Oligopéptidos/administración & dosificación; Oligopéptidos/química; Ratas; Ratas Sprague-Dawley; Reproducibilidad de los Resultados; Sensibilidad y Especificidad

Palabras clave

MMAE; antibody-drug conjugate; bioanalysis; liquid chromatography-qTOF-MS/MS

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oligopéptidos / Espectrometría de Masas / Cromatografía Liquida Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Chromatogr Año: 2020 Tipo del documento: Article País de afiliación: Corea del Sur

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