Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae.
Biomed Opt Express
; 11(4): 2137-2151, 2020 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-32341872
ABSTRACT
We present a dual modality functional optical coherence tomography and photoacoustic microscopy (OCT-PAM) system. The photoacoustic modality employs an akinetic optical sensor with a large imaging window. This imaging window enables direct reflection mode operation, and a seamless integration of optical coherence tomography (OCT) as a second imaging modality. Functional extensions to the OCT-PAM system include Doppler OCT (DOCT) and spectroscopic PAM (sPAM). This functional and non-invasive imaging system is applied to image zebrafish larvae, demonstrating its capability to extract both morphological and hemodynamic parameters in vivo in small animals, which are essential and critical in preclinical imaging for physiological, pathophysiological and drug response studies.
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MEDLINE
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En
Revista:
Biomed Opt Express
Año:
2020
Tipo del documento:
Article
País de afiliación:
Austria