Reversal of Cardiac Hypertrophy With a Ketogenic Diet in a Child With Mitochondrial Disease and Hypertrophic Cardiomyopathy.
Can J Cardiol
; 36(10): 1690.e1-1690.e3, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32360196
ABSTRACT
Mitochondrial diseases are rare metabolic disorders that can cause hypertrophic cardiomyopathy. Herein we describe the case of a 3-year-old girl diagnosed with mitochondrial disease (mutation m.5559A>G in the mitochondrial-tRNATrp gene). Echocardiography showed left ventricular hypertrophy with an enlarged septum (9 mm, z score = 3.26). Antioxidant supplementation associated with a high-fat ketogenic diet was introduced and, as expected, improved neurologic status. In addition, heart parameters improved with normalisation of interventricular septum thickness at 6 years of age (6 mm, z score = 1.05). In this case report, we suggest that a ketogenic diet may improve hypertrophic cardiomyopathy in the context of mitochondrial disease.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Hipertrófica
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ARN de Transferencia de Triptófano
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Ecocardiografía
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Enfermedades Mitocondriales
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Dieta Cetogénica
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Ventrículos Cardíacos
Tipo de estudio:
Etiology_studies
Límite:
Child, preschool
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Female
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Humans
Idioma:
En
Revista:
Can J Cardiol
Asunto de la revista:
CARDIOLOGIA
Año:
2020
Tipo del documento:
Article