Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior.

Schuster, Benjamin S; Dignon, Gregory L; Tang, Wai Shing; Kelley, Fleurie M; Ranganath, Aishwarya Kanchi; Jahnke, Craig N; Simpkins, Alison G; Regy, Roshan Mammen; Hammer, Daniel A; Good, Matthew C; Mittal, Jeetain

Schuster, Benjamin S; Dignon, Gregory L; Tang, Wai Shing; Kelley, Fleurie M; Ranganath, Aishwarya Kanchi; Jahnke, Craig N; Simpkins, Alison G; Regy, Roshan Mammen; Hammer, Daniel A; Good, Matthew C; Mittal, Jeetain.

Afiliación

Schuster BS; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.
Dignon GL; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854.
Tang WS; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015.
Kelley FM; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.
Ranganath AK; Department of Physics, Brown University, Providence, RI 02912.
Jahnke CN; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854.
Simpkins AG; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 08854.
Regy RM; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Hammer DA; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Good MC; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015.
Mittal J; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.

Proc Natl Acad Sci U S A ; 117(21): 11421-11431, 2020 05 26.

Article en En | MEDLINE | ID: mdl-32393642

Asunto(s)

Proteínas de Caenorhabditis elegans/química; Proteínas Intrínsecamente Desordenadas/química; ARN Helicasas/química; Sustitución de Aminoácidos; Arginina/química; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Citoplasma/metabolismo; Interacciones Hidrofóbicas e Hidrofílicas; Proteínas Intrínsecamente Desordenadas/genética; Proteínas Intrínsecamente Desordenadas/metabolismo; Microorganismos Modificados Genéticamente; Simulación de Dinámica Molecular; Transición de Fase; Dominios Proteicos; ARN Helicasas/genética; ARN Helicasas/metabolismo; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/metabolismo; Temperatura; Tirosina/química

Palabras clave

liquidliquid phase separation; membraneless organelles; molecular simulations

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN Helicasas / Proteínas de Caenorhabditis elegans / Proteínas Intrínsecamente Desordenadas Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google