Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.

Shan, Baixi; Ai, Zhifu; Zeng, Sufen; Song, Yonggui; Song, Jiagui; Zeng, Qiang; Liao, Zhou; Wang, Tingting; Huang, Chao; Su, Dan

Shan, Baixi; Ai, Zhifu; Zeng, Sufen; Song, Yonggui; Song, Jiagui; Zeng, Qiang; Liao, Zhou; Wang, Tingting; Huang, Chao; Su, Dan.

Afiliación

Shan B; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Ai Z; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Zeng S; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Song Y; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China. Electronic address: songyonggui1999@163.com.
Song J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China.
Zeng Q; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Liao Z; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Wang T; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Huang C; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China.
Su D; Laboratory Animal Science and Technology Center, College of Pharmacy, College of Science and Technology, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Road, Nanchang, 330004, China. Electronic address: sud94@aliyun.com.

Psychoneuroendocrinology ; 117: 104699, 2020 07.

Article en En | MEDLINE | ID: mdl-32402927

Asunto(s)

Ansiedad; Conducta Animal/fisiología; Disfunción Cognitiva/metabolismo; Microbioma Gastrointestinal/fisiología; Hipocampo/metabolismo; Ácido Láctico/efectos adversos; Metaboloma/fisiología; Receptores Acoplados a Proteínas G/metabolismo; Transducción de Señal/fisiología; Estrés Psicológico; Animales; Ansiedad/metabolismo; Ansiedad/microbiología; Ansiedad/fisiopatología; Modelos Animales de Enfermedad; Masculino; ARN Ribosómico 16S; Ratas; Estrés Psicológico/metabolismo; Estrés Psicológico/microbiología; Estrés Psicológico/fisiopatología

Palabras clave

16S rRNA; Anxiety; GPR81; Gut microbiome; Lactate; Metabonomics

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ansiedad / Estrés Psicológico / Conducta Animal / Transducción de Señal / Ácido Láctico / Receptores Acoplados a Proteínas G / Metaboloma / Disfunción Cognitiva / Microbioma Gastrointestinal / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Psychoneuroendocrinology Año: 2020 Tipo del documento: Article País de afiliación: China

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