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Analysis of mutations of PARP1, RNF213, PAX8, KMT2C, MTRR in malignant mesothelioma of testicular tunica vaginalis testis.
Kowalik, Artur; Wincewicz, Andrzej; Zieba, Sebastian; Baran, Wojciech; Kopczynski, Janusz; Koda, Mariusz; Sulkowski, Stanislaw; Gozdz, Stanislaw.
Afiliación
  • Kowalik A; Department of Molecular Diagnostics, Holy Cross Oncology Centre, Kielce, Poland.
  • Wincewicz A; Division of Medical Biology, Institute of Biology Jan Kochanowski University, Kielce, Poland.
  • Zieba S; Division of Medical Biology, Institute of Biology Jan Kochanowski University, Kielce, Poland.
  • Baran W; Department of Molecular Diagnostics, Holy Cross Oncology Centre, Kielce, Poland.
  • Kopczynski J; Department of Urology, Saint Raphael Voivodship Specialist Hospital, Checiny, Poland.
  • Koda M; Department of Pathology, Holy Cross Oncology Centre, Kielce, Poland.
  • Sulkowski S; Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
  • Gozdz S; Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
Pol J Pathol ; 71(1): 69-74, 2020.
Article en En | MEDLINE | ID: mdl-32429658
ABSTRACT
Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man. Multifocal papillary-solid areas contained necrosis among highly cellular fields with multiple mitoses. It was positive for WT1, CKAE1/AE3, calretinin, CK7 with negativity for CK5, PSA, TTF-1. Following mutations were revealed in PARP1 (NM_001618 c.2285TG, p.K135R), MTRR (NM_024010 c.147A>G, p.I49M) and two sorts of mutations in structure of KMT2C gene (NM_170606 c.2447_2448insA (c.2447dupA), p.Y816fs and NM_170606 c.1042G>A, p.D348N) for the first time in MMTVT.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Mesotelioma Límite: Aged80 / Humans / Male Idioma: En Revista: Pol J Pathol Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Polonia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Testiculares / Mesotelioma Límite: Aged80 / Humans / Male Idioma: En Revista: Pol J Pathol Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Polonia