Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2.

Faber, Erik B; Tian, Defeng; Burban, David; Levinson, Nicholas M; Hawkinson, Jon E; Georg, Gunda I

Faber, Erik B; Tian, Defeng; Burban, David; Levinson, Nicholas M; Hawkinson, Jon E; Georg, Gunda I.

Afiliación

Faber EB; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Tian D; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Burban D; Department of Pharmacology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Levinson NM; Department of Pharmacology, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Hawkinson JE; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414, United States.
Georg GI; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414, United States.

ACS Chem Biol ; 15(7): 1759-1764, 2020 07 17.

Article en En | MEDLINE | ID: mdl-32433863

Asunto(s)

Naftalenosulfonatos de Anilina/química; Óxidos N-Cíclicos/química; Quinasa 2 Dependiente de la Ciclina/antagonistas & inhibidores; Indolizinas/química; Inhibidores de Proteínas Quinasas/química; Compuestos de Piridinio/química; Roscovitina/química; Regulación Alostérica; Naftalenosulfonatos de Anilina/metabolismo; Óxidos N-Cíclicos/metabolismo; Quinasa 2 Dependiente de la Ciclina/metabolismo; Sinergismo Farmacológico; Humanos; Indolizinas/metabolismo; Simulación del Acoplamiento Molecular; Unión Proteica; Inhibidores de Proteínas Quinasas/metabolismo; Compuestos de Piridinio/metabolismo; Roscovitina/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos de Piridinio / Óxidos N-Cíclicos / Inhibidores de Proteínas Quinasas / Quinasa 2 Dependiente de la Ciclina / Roscovitina / Indolizinas / Naftalenosulfonatos de Anilina Límite: Humans Idioma: En Revista: ACS Chem Biol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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