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Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.
Klemm, Florian; Maas, Roeltje R; Bowman, Robert L; Kornete, Mara; Soukup, Klara; Nassiri, Sina; Brouland, Jean-Philippe; Iacobuzio-Donahue, Christine A; Brennan, Cameron; Tabar, Viviane; Gutin, Philip H; Daniel, Roy T; Hegi, Monika E; Joyce, Johanna A.
Afiliación
  • Klemm F; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
  • Maas RR; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland; Neuroscience Research Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Department of Neurosurgery, Centre Hospitalier Un
  • Bowman RL; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Kornete M; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
  • Soukup K; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.
  • Nassiri S; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland; Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Brouland JP; Department of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Iacobuzio-Donahue CA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Brennan C; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Tabar V; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Gutin PH; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Daniel RT; Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Hegi ME; Neuroscience Research Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
  • Joyce JA; Department of Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland. Electronic address: johanna.joyce@unil.ch.
Cell ; 181(7): 1643-1660.e17, 2020 06 25.
Article en En | MEDLINE | ID: mdl-32470396
ABSTRACT
Brain malignancies encompass a range of primary and metastatic cancers, including low-grade and high-grade gliomas and brain metastases (BrMs) originating from diverse extracranial tumors. Our understanding of the brain tumor microenvironment (TME) remains limited, and it is unknown whether it is sculpted differentially by primary versus metastatic disease. We therefore comprehensively analyzed the brain TME landscape via flow cytometry, RNA sequencing, protein arrays, culture assays, and spatial tissue characterization. This revealed disease-specific enrichment of immune cells with pronounced differences in proportional abundance of tissue-resident microglia, infiltrating monocyte-derived macrophages, neutrophils, and T cells. These integrated analyses also uncovered multifaceted immune cell activation within brain malignancies entailing converging transcriptional trajectories while maintaining disease- and cell-type-specific programs. Given the interest in developing TME-targeted therapies for brain malignancies, this comprehensive resource of the immune landscape offers insights into possible strategies to overcome tumor-supporting TME properties and instead harness the TME to fight cancer.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Microambiente Tumoral / Glioma Límite: Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Suiza
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Microambiente Tumoral / Glioma Límite: Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Suiza