[Biomononitoring of environmental exposure to inorganic arsenic]. / Surveillance biologique de l'exposition environnementale à l'arsenic inorganique.
Ann Biol Clin (Paris)
; 78(3): 279-298, 2020 06 01.
Article
en Fr
| MEDLINE
| ID: mdl-32540815
ABSTRACT
BACKGROUND AND OBJECTIVES:
The French national authority for health (Haute autorité de santé HAS) and the French clinical toxicology society (Société de toxicologie clinique STC) received a formal request from the French ministry for heath to elaborate recommendations for the screening of environmental overexposure to inorganic arsenic (iAs), for the medical management of overexposed patients and for the medical surveillance of exposed population. To allow these recommendations, preliminary literature retrieval and analysis were performed for identifying validated indicators of both exposure and early effects of iAs and their levels in the general population living in France.METHODS:
Evaluations of inorganic arsenic toxicity conducted by national or international health agencies during the last 3 decades were all examined and analyzed. These evaluations were completed by literature retrieval through Medline and Scopus from January 2016 to December 2019. RESULTS ANDCONCLUSIONS:
The best biomonitoring indicator for iAs exposure is the sum of urine iAs, monmomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) concentrations (SAs). The upper limit of confidence interval of the 95th percentile of the distribution of this parameter in the general adult population living in France is 10 µg/g of creatinine, and is recommended as the limit value for the definition of overexposure. In less than 12 year-old children specific limit values are required, but not yet available. In their absence, SAs should exceed both 10 µg/g creatinine and 11 µg/L to be considered as indicating a probable overexposure to iAs. There are no useful biological indicators of iAs early effects. Non carcinogenic skin effects of inorganic arsenic (hyperpigmentation and keratosis) should be considered as the earliest deleterious effects of repeated environmental iAs exposure.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arsénico
/
Intoxicación por Arsénico
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Exposición a Riesgos Ambientales
/
Monitoreo Biológico
Tipo de estudio:
Evaluation_studies
/
Guideline
/
Prognostic_studies
/
Screening_studies
Límite:
Adult
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Child
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Child, preschool
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Humans
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Infant
/
Newborn
País/Región como asunto:
Europa
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Año:
2020
Tipo del documento:
Article