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Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects.
Omar, Abdelsattar M; Bajorath, Jürgen; Ihmaid, Saleh; Mohamed, Hany M; El-Agrody, Ahmed M; Mora, Ahmed; El-Araby, Moustafa E; Ahmed, Hany E A.
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  • Omar AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11884 Nasr City, Cairo, Egypt. Electronic address: asmansour@kau.edu.sa.
  • Bajorath J; Department of Life Science Informatics, Bonn-Aachen International Center for Information Technology, Rheinische Friedrich-Wilhelms-Universität Bonn Endenicher Allee 19c, D-53115 Bonn, Germany.
  • Ihmaid S; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia. Electronic address: saleh_ihmaid@yahoo.com.au.
  • Mohamed HM; Chemistry Department, Faculty of Science, Jazan University, Jazan 45142, Saudi Arabia; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
  • El-Agrody AM; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
  • Mora A; Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
  • El-Araby ME; Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  • Ahmed HEA; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Bioorg Chem ; 101: 103992, 2020 08.
Article en En | MEDLINE | ID: mdl-32554279
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Triazoles / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz / Fragmentación del ADN / Descubrimiento de Drogas / Puntos de Control del Ciclo Celular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Triazoles / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz / Fragmentación del ADN / Descubrimiento de Drogas / Puntos de Control del Ciclo Celular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article