Genital verruciform xanthoma: lessons from a contemporary multi-institutional series.
Histopathology
; 77(5): 841-846, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32598505
ABSTRACT
AIMS:
Verruciform xanthoma (VX) is an uncommon lesion, seen in the oral mucosa and rarely occurring at cutaneous genital sites. Reports of exceptional VX presentations dominate the literature; herein, we assess the clinical and histological features of a cohort of routine, consecutive cases. METHODS ANDRESULTS:
Clinicopathological features of genital VXs from four academic centres were reviewed. A cohort of 25 lesions from 24 patients (22 male, two female; median age = 62 years), occurred on the scrotum (84%), penis (8%) and perineum/vulva (8%). VX was never suspected clinically; considerations ranged from fibroepithelial polyps to squamous cell carcinoma. Classic diagnostic criteria were present at least focally in each lesion, including verrucous architecture, prominent wedge-shaped parakeratosis extending between exophytic epidermal projections and neutrophils in the stratum corneum. Xanthomatous cells were present in all cases, but scattered to rare in 24%.CONCLUSIONS:
Consecutive genital VXs reliably exhibited classic histopathological features, although the essential finding of xanthomatous cells may be scarce. Our comparison to meta-analyses of published cases found relatively fewer penile and vulvar examples. Additionally, the median age was older than in published series, which have emphasised syndromic associations.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Xantomatosis
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Enfermedades de los Genitales Femeninos
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Enfermedades de los Genitales Masculinos
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Histopathology
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos