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A new diterpenoid from the leaves of Phyllanthus acidus.
Duong, Thuc-Huy; Trung, Nguyen Tien; Phan, Cam-Tu Dang; Nguyen, Vu-Duy; Nguyen, Hoang-Chuong; Dao, Thi-Bich-Ngoc; Mai, Dinh-Tri; Niamnont, Nakorn; Tran, Thi-Ngoc-Mai; Sichaem, Jirapast.
Afiliación
  • Duong TH; Faculty of Chemistry, University of Education, Ho Chi Minh City, Vietnam.
  • Trung NT; Laboratory of Computational Chemistry and Modelling (LCCM), Faculty of Natural Sciences, Quy Nhon University, Qui NhÆ¡n, Vietnam.
  • Phan CD; Laboratory of Computational Chemistry and Modelling (LCCM), Faculty of Natural Sciences, Quy Nhon University, Qui NhÆ¡n, Vietnam.
  • Nguyen VD; Faculty of Chemistry, University of Education, Ho Chi Minh City, Vietnam.
  • Nguyen HC; University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
  • Dao TB; Faculty of Chemistry, University of Education, Ho Chi Minh City, Vietnam.
  • Mai DT; Graduate University of Science and Technology, Viet Nam Academy of Science and Technology, Hanoi, Vietnam.
  • Niamnont N; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.
  • Tran TN; Faculty of Science, Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
  • Sichaem J; Institute of Applied Sciences, Ho Chi Minh City University of Technology (HUTECH), Ho Chi Minh City, Vietnam.
Nat Prod Res ; 36(2): 539-545, 2022 Jan.
Article en En | MEDLINE | ID: mdl-32643407
ABSTRACT
A new diterpenoid, phyllane C (1), along with three known compounds, ovoideal E (2), spruceanol (3), and fluacinoid B (4) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1. Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL).
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Phyllanthus / Diterpenos Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Vietnam
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Phyllanthus / Diterpenos Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Vietnam