Molecular mechanisms of sex bias differences in COVID-19 mortality.
Li, Yuchong; Jerkic, Mirjana; Slutsky, Arthur S; Zhang, Haibo.
Crit Care;
24(1): 405, 2020 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32646459
More men than women have died from COVID-19. Genes encoded on X chromosomes, and sex hormones may explain the decreased fatality of COVID-19 in women. The angiotensin-converting enzyme 2 gene is located on X chromosomes. Men, with a single X chromosome, may lack the alternative mechanism for cellular protection after exposure to SARS-CoV-2. Some Toll-like receptors encoded on the X chromosomes can sense SARS-CoV-2 nucleic acids, leading to a stronger innate immunity response in women. Both estrogen and estrogen receptor-α contribute to T cell activation. Interventional approaches including estrogen-related compounds and androgen receptor antagonists may be considered in patients with COVID-19.
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