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Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila.
Segura Munoz, Rafael R; Quach, Truyen; Gomes-Neto, João C; Xian, Yibo; Pena, Pamela A; Weier, Steven; Pellizzon, Michael A; Kittana, Hatem; Cody, Liz A; Geis, Abby L; Heck, Kari; Schmaltz, Robert J; Bindels, Laure B; Cahoon, Edgar B; Benson, Andrew K; Clemente, Tom Elmo; Ramer-Tait, Amanda E.
Afiliación
  • Segura Munoz RR; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Quach T; Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Gomes-Neto JC; Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
  • Xian Y; Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Pena PA; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Weier S; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Pellizzon MA; Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Kittana H; Department of Agronomy and Horticulture, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.
  • Cody LA; Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Geis AL; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Heck K; Research Diets, Inc, New Brunswick, NJ, 08901, USA.
  • Schmaltz RJ; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Bindels LB; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Cahoon EB; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Benson AK; Arkansas College of Osteopathic Medicine, Fort Smith, AR, 72916, USA.
  • Clemente TE; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
  • Ramer-Tait AE; Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.
Mol Nutr Food Res ; 64(17): e2000162, 2020 09.
Article en En | MEDLINE | ID: mdl-32656952
ABSTRACT
SCOPE Previous studies have suggested that diets rich in omega-3 and low in omega-6 long-chain polyunsaturated fatty acids (PUFAs) can limit the development of metabolic syndrome (MetS). Transgenic soybeans yielding oils enriched for omega-3 PUFAs represent a new and readily-available option for incorporating omega-3 PUFAs into diets to provide health benefits. METHODS AND

RESULTS:

Transgenic soybean oils, enriched for either stearidonic acid (SDA) or eicosapentaenoic acid (EPA), are incorporated into diets to test their effects on limiting the development of MetS in a mouse model of diet-induced obesity. Supplementation with SDA- but not EPA-enriched oils improved features of MetS compared to feeding a control wild-type oil. Because previous studies have linked the gut microorganism Akkermansia muciniphila to the metabolic effects of feeding omega-3 PUFAs, the causal contribution of A. muciniphila to mediating the metabolic benefits provided by SDA-enriched diets is investigated. Although A. muciniphila is not required for SDA-induced metabolic improvements, this microorganism does modulate levels of saturated and mono-unsaturated fatty acids in host adipose tissues.

CONCLUSION:

Together, these findings support the utilization of SDA-enriched diets to modulate weight gain, glucose metabolism, and fatty acid profiles of liver and adipose tissue.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aceite de Soja / Ácidos Grasos Omega-3 / Glucosa / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aceite de Soja / Ácidos Grasos Omega-3 / Glucosa / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos