Neurodevelopmental outcome and respiratory management of congenital central hypoventilation syndrome: a retrospective study.
BMC Pediatr
; 20(1): 342, 2020 07 13.
Article
en En
| MEDLINE
| ID: mdl-32660452
ABSTRACT
BACKGROUND:
Congenital central hypoventilation syndrome (CCHS) is a rare disease characterized by sleep apnea. Anoxia often occurs soon after birth, and it is important to prevent anoxia-mediated central nervous system complications; however, data on the relationship between respiratory management and the prognosis for intellectual development of patients with CCHS is not well yet investigate.METHODS:
We performed a retrospective chart review cohort study of patients with CCHS in Japan. We investigated the risk and prognostic factors for developmental outcomes and examined the disease in terms of its symptoms, diagnosis, complications, and treatment.RESULTS:
Of the 123 patients with CCHS included in the survey, 88 patients were 6 years old and older. They were divided into two group based on their intelligence quotient. Those treated using positive-pressure ventilation via tracheostomy in the first three months of life had a better developmental prognosis than those managed via tracheostomy after three months of age and those treated by ventilation using mask (OR = 3.80; 95% CI 1.00-14.37, OR = 4.65; 95% CI 1.11-19.37). There was no significant difference in physical development (P = 0.64).CONCLUSIONS:
The best respiratory treatment for patients with CCHS is ventilation via tracheostomy, initiated ideally before the age of three months.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Apnea Central del Sueño
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Child
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Humans
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Infant
País/Región como asunto:
Asia
Idioma:
En
Revista:
BMC Pediatr
Asunto de la revista:
PEDIATRIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón