Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults.
Neuroimage
; 221: 117152, 2020 11 01.
Article
en En
| MEDLINE
| ID: mdl-32668299
There is a growing consensus regarding the positive relationship between physical function and working memory; however, explanations of task-evoked functional activity regarding this relationship and its differences in physical function domains remain controversial. This study illustrates the cross-sectional relationships between cardiorespiratory fitness, gait speed, hand dexterity, and muscular strength with working memory task (N-back task) performance and the mediating effects of task-evoked functional activity in 1033 adults aged between 22 and 37 years. The results showed that cardiorespiratory fitness and hand dexterity were independently associated with N-back task performance to a greater extent and in contrast to gait speed and muscular strength. These relationships were mediated by task-evoked functional activity in a part of the frontoparietal network (FPN) and default mode network (DMN). Superior cardiorespiratory fitness could contribute to working memory performance by enhancing the compensational role of FPN-related broader region activation. Hand dexterity was associated with moderation of the interaction in terms of task-evoked activation between the FPN and DMN, which in turn, improved N-back task performance. Based on these findings, we conclude that cardiorespiratory fitness and hand dexterity have common and unique mechanisms enhancing working memory.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
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Corteza Cerebral
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Fuerza Muscular
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Conectoma
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Velocidad al Caminar
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Capacidad Cardiovascular
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Memoria a Corto Plazo
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Destreza Motora
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Red Nerviosa
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroimage
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón