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Identification of the brain networks that contribute to the interaction between physical function and working memory: An fMRI investigation with over 1,000 healthy adults.
Ishihara, Toru; Miyazaki, Atsushi; Tanaka, Hiroki; Matsuda, Tetsuya.
Afiliación
  • Ishihara T; Tamagawa University Brain Science Institute, Tokyo, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
  • Miyazaki A; Tamagawa University Brain Science Institute, Tokyo, Japan.
  • Tanaka H; Tamagawa University Brain Science Institute, Tokyo, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
  • Matsuda T; Tamagawa University Brain Science Institute, Tokyo, Japan. Electronic address: tetsuya@lab.tamagawa.ac.jp.
Neuroimage ; 221: 117152, 2020 11 01.
Article en En | MEDLINE | ID: mdl-32668299
There is a growing consensus regarding the positive relationship between physical function and working memory; however, explanations of task-evoked functional activity regarding this relationship and its differences in physical function domains remain controversial. This study illustrates the cross-sectional relationships between cardiorespiratory fitness, gait speed, hand dexterity, and muscular strength with working memory task (N-back task) performance and the mediating effects of task-evoked functional activity in 1033 adults aged between 22 and 37 years. The results showed that cardiorespiratory fitness and hand dexterity were independently associated with N-back task performance to a greater extent and in contrast to gait speed and muscular strength. These relationships were mediated by task-evoked functional activity in a part of the frontoparietal network (FPN) and default mode network (DMN). Superior cardiorespiratory fitness could contribute to working memory performance by enhancing the compensational role of FPN-related broader region activation. Hand dexterity was associated with moderation of the interaction in terms of task-evoked activation between the FPN and DMN, which in turn, improved N-back task performance. Based on these findings, we conclude that cardiorespiratory fitness and hand dexterity have common and unique mechanisms enhancing working memory.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Corteza Cerebral / Fuerza Muscular / Conectoma / Velocidad al Caminar / Capacidad Cardiovascular / Memoria a Corto Plazo / Destreza Motora / Red Nerviosa Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2020 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Corteza Cerebral / Fuerza Muscular / Conectoma / Velocidad al Caminar / Capacidad Cardiovascular / Memoria a Corto Plazo / Destreza Motora / Red Nerviosa Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2020 Tipo del documento: Article País de afiliación: Japón