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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
Shwartz, Yulia; Gonzalez-Celeiro, Meryem; Chen, Chih-Lung; Pasolli, H Amalia; Sheu, Shu-Hsien; Fan, Sabrina Mai-Yi; Shamsi, Farnaz; Assaad, Steven; Lin, Edrick Tai-Yu; Zhang, Bing; Tsai, Pai-Chi; He, Megan; Tseng, Yu-Hua; Lin, Sung-Jan; Hsu, Ya-Chieh.
Afiliación
  • Shwartz Y; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Gonzalez-Celeiro M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
  • Chen CL; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.
  • Pasolli HA; Electron Microscopy Resource Center, The Rockefeller University, New York, NY 10065, USA.
  • Sheu SH; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
  • Fan SM; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.
  • Shamsi F; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
  • Assaad S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Lin ET; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan.
  • Zhang B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Tsai PC; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • He M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Tseng YH; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
  • Lin SJ; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei 100, Taiwan; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan; Research Center for Development
  • Hsu YC; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: yachieh_hsu@harvard.edu.
Cell ; 182(3): 578-593.e19, 2020 08 06.
Article en En | MEDLINE | ID: mdl-32679029
Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili muscle (APM), and the sympathetic nerve, providing a model to study interactions across epithelium, mesenchyme, and nerves. Here, we show that APMs and sympathetic nerves form a dual-component niche to modulate hair follicle stem cell (HFSC) activity. Sympathetic nerves form synapse-like structures with HFSCs and regulate HFSCs through norepinephrine, whereas APMs maintain sympathetic innervation to HFSCs. Without norepinephrine signaling, HFSCs enter deep quiescence by down-regulating the cell cycle and metabolism while up-regulating quiescence regulators Foxp1 and Fgf18. During development, HFSC progeny secretes Sonic Hedgehog (SHH) to direct the formation of this APM-sympathetic nerve niche, which in turn controls hair follicle regeneration in adults. Our results reveal a reciprocal interdependence between a regenerative tissue and its niche at different stages and demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre / Transducción de Señal / Norepinefrina / Folículo Piloso / Proteínas Hedgehog / Nervio Accesorio / Cabello Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre / Transducción de Señal / Norepinefrina / Folículo Piloso / Proteínas Hedgehog / Nervio Accesorio / Cabello Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos