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The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.
Thompson, Elizabeth D; Roberts, Nicholas J; Wood, Laura D; Eshleman, James R; Goggins, Michael G; Kern, Scott E; Klein, Alison P; Hruban, Ralph H.
Afiliación
  • Thompson ED; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Roberts NJ; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Wood LD; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Eshleman JR; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Goggins MG; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kern SE; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Klein AP; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hruban RH; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mod Pathol ; 33(12): 2544-2563, 2020 12.
Article en En | MEDLINE | ID: mdl-32704031
ABSTRACT
The publication of the "Pan-Cancer Atlas" by the Pan-Cancer Analysis of Whole Genomes Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC), provides a wonderful opportunity to reflect on where we stand in our understanding of the genetics of pancreatic cancer, as well as on the opportunities to translate this understanding to patient care. From germline variants that predispose to the development of pancreatic cancer, to somatic mutations that are therapeutically targetable, genetics is now providing hope, where there once was no hope, for those diagnosed with pancreatic cancer.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Variación Genética / Biomarcadores de Tumor / Carcinoma Ductal Pancreático / Genómica / Técnicas de Diagnóstico Molecular Tipo de estudio: Diagnostic_studies / Prognostic_studies / Sysrev_observational_studies Límite: Animals / Humans Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Variación Genética / Biomarcadores de Tumor / Carcinoma Ductal Pancreático / Genómica / Técnicas de Diagnóstico Molecular Tipo de estudio: Diagnostic_studies / Prognostic_studies / Sysrev_observational_studies Límite: Animals / Humans Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos