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Impact of supervised exercise training on pulmonary function parameters, exercise capacity and Irisin Biomarker in Interstitial lung disease patients.
Alyami, Rahma Mohammad; Alhowikan, Abdulrahman Mohammed; Alharbi, Abdullah Rashed; Al-Nafisah, Ghada.
Afiliación
  • Alyami RM; Rahma Mohammad Alyami, MS. College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Alhowikan AM; Abdulrahman Mohammed Alhowikan, PhD. Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alharbi AR; Abdullah Rashed Alharbi, MBBS. Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Al-Nafisah G; Ghada AL-Nafisah, MS. Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Pak J Med Sci ; 36(5): 1089-1095, 2020.
Article en En | MEDLINE | ID: mdl-32704295
ABSTRACT

OBJECTIVES:

To assess the impact of supervised exercise training (SET) on pulmonary function Parameters, exercise capacity and Irisin biomarker in Interstitial Lung Disease (ILD) patients.

METHODS:

Ten (10)patients with ILD and 18 healthy controls of age between 30-40+ years were selected for 8-week SET program. Before and after SET all subjects performed exercise capacity six minutes' walk test (6MWT), heart rate (HR) changes were recorded, shortness of Breath Respiratory Questionnaire (SOBQ) was obtained and Irisin levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). This interventional study was carried out at Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2018 to February 2019.

RESULTS:

Mean six minutes' walk distance (6MWD) was 395 ± 68.4 m at 1st visit increased significantly (p=0.001) to 458.8± 87.1 mat 15 visit. However, 6MWD values found significantly higher in controls (517.4±84.1 m; 561.7±81.6 m; p=0.013) than ILD patients. Overall change (difference between post and pre exercise) in HRvalue was recorded lower in ILD patients (30-35 bpm) as compared to controls (40-45 bpm). Moreover, ILD patients had overall higher SOBQ score than controls. Pre SET Irisin levels of ILD patients (4.24 ±1.73 pg/ml) and controls (3.43 ±1.04pg/ml) were found unchanged dafter SET (4.48±2.02pg/ml, 3.39 ±1.41pg/ml, p=0.677, p=0.093)respectively. However, patients Irisin values were found higher as compared to controls before and after SET.

CONCLUSION:

Exercise capacity and Dyspneain patients with ILD were improved after 8-week of SET program. No major changes in Irisin levels among patients with ILD and controls were observed. Additional research requires to be carried out on large number of subjects to deter Minutese the advantages of exercise in ILD.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Pak J Med Sci Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Pak J Med Sci Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita