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15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling.
Endo, Suzu; Suganami, Akiko; Fukushima, Keijo; Senoo, Kanaho; Araki, Yumi; Regan, John W; Mashimo, Masato; Tamura, Yutaka; Fujino, Hiromichi.
Afiliación
  • Endo S; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
  • Suganami A; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Fukushima K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
  • Senoo K; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
  • Araki Y; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
  • Regan JW; Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.
  • Mashimo M; Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto, Japan.
  • Tamura Y; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: yutaka_tamura@faculty.chiba-u.jp.
  • Fujino H; Department of Pharmacology for Life Sciences, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan. Electronic address: hfujino@tokushima-u.ac.jp.
J Biol Chem ; 295(38): 13338-13352, 2020 09 18.
Article en En | MEDLINE | ID: mdl-32727851
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Simulación por Computador / Dinoprostona / Transducción de Señal / Subtipo EP2 de Receptores de Prostaglandina E / Modelos Biológicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Japón
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Simulación por Computador / Dinoprostona / Transducción de Señal / Subtipo EP2 de Receptores de Prostaglandina E / Modelos Biológicos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Japón