Specific Mutations in APC, but Not Alterations in DNA Damage Response, Associate With Outcomes of Patients With Metastatic Colorectal Cancer.

Mondaca, Sebastian; Walch, Henry; Nandakumar, Subhiksha; Chatila, Walid K; Schultz, Nikolaus; Yaeger, Rona

Mondaca, Sebastian; Walch, Henry; Nandakumar, Subhiksha; Chatila, Walid K; Schultz, Nikolaus; Yaeger, Rona.

Afiliación

Mondaca S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Walch H; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Nandakumar S; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Chatila WK; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York; Tri-Institutional Program in Computational Biology and Medicine, Weill Cornell Medical College, New York, New York.
Schultz N; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cance
Yaeger R; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: yaegerr@mskcc.org.

Gastroenterology ; 159(5): 1975-1978.e4, 2020 11.

Article en En | MEDLINE | ID: mdl-32730818

Asunto(s)

Proteína de la Poliposis Adenomatosa del Colon/genética; Biomarcadores de Tumor/genética; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/genética; Daño del ADN; Mutación; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Toma de Decisiones Clínicas; Neoplasias Colorrectales/mortalidad; Neoplasias Colorrectales/patología; Análisis Mutacional de ADN; Resistencia a Antineoplásicos; Predisposición Genética a la Enfermedad; Humanos; Metástasis de la Neoplasia; Fenotipo; Medicina de Precisión; Supervivencia sin Progresión; Factores de Tiempo

Palabras clave

APC; Colorectal Cancer; DNA Damage Response

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Daño del ADN / Neoplasias Colorrectales / Biomarcadores de Tumor / Proteína de la Poliposis Adenomatosa del Colon / Mutación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Gastroenterology Año: 2020 Tipo del documento: Article

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