Your browser doesn't support javascript.
loading
Repair of alveolar cleft bone defects by bone collagen particles combined with human umbilical cord mesenchymal stem cells in rabbit.
Sun, Xue-Cheng; Wang, Hu; Li, Jian-Hui; Zhang, Dan; Yin, Li-Qiang; Yan, Yu-Fang; Ma, Xu; Xia, Hong-Fei.
Afiliación
  • Sun XC; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 10081, China.
  • Wang H; Graduate Schools, Peking Union Medical College, Beijing, 100730, China.
  • Li JH; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 10081, China.
  • Zhang D; Graduate Schools, Peking Union Medical College, Beijing, 100730, China.
  • Yin LQ; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 10081, China.
  • Yan YF; Graduate Schools, Peking Union Medical College, Beijing, 100730, China.
  • Ma X; Reproductive and Genetic Center of National Research Institute for Family Planning, Beijing, 10081, China.
  • Xia HF; Graduate Schools, Peking Union Medical College, Beijing, 100730, China.
Biomed Eng Online ; 19(1): 62, 2020 Aug 03.
Article en En | MEDLINE | ID: mdl-32746926
BACKGROUND: Alveolar cleft is a type of cleft lip and palate that seriously affects the physical and mental health of patients. In this study, a model of the alveolar cleft phenotype was established in rabbits to evaluate the effect of bone collagen particles combined with human umbilical cord mesenchymal stem cells (HUC-MSCs) on the repair of alveolar cleft bone defects. METHODS: A model of alveolar clefts in rabbits was established by removing the incisors on the left side of the upper jaw bone collagen particles combined with HUC-MSCs that were then implanted in the defect area. Blood biochemical analysis was performed 3 months after surgery. Skull tissues were harvested for gross observation, and micro-focus computerised tomography (micro-CT) analysis. Tissues were harvested for histological and immunohistochemical staining. The experiments were repeated 6 months after surgery. RESULTS: Bone collagen particles and HUC-MSCs showed good biocompatibility. Bone collagen particles combined with HUC-MSCs were markedly better at inducing bone repair and regeneration than bone collagen particles alone. CONCLUSIONS: Combining HUC-MSCs with bone collagen particles provides a simple, rapid and suitable method to fill a bone defect site and treat of alveolar cleft bone defects.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cordón Umbilical / Colágeno / Labio Leporino / Trasplante de Células Madre Mesenquimatosas Límite: Animals / Humans / Male Idioma: En Revista: Biomed Eng Online Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cordón Umbilical / Colágeno / Labio Leporino / Trasplante de Células Madre Mesenquimatosas Límite: Animals / Humans / Male Idioma: En Revista: Biomed Eng Online Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China