Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
Pharmacogenomics
; 21(13): 903-917, 2020 08.
Article
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| MEDLINE
| ID: mdl-32757697
ABSTRACT
Aim:
Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients &methods:
One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls.Results:
Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541.Conclusion:
This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Receptores de Neuropéptido Y
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Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
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Receptor de Galanina Tipo 1
/
Trastornos Relacionados con Opioides
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
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Male
Idioma:
En
Revista:
Pharmacogenomics
Asunto de la revista:
FARMACOLOGIA
/
GENETICA MEDICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos