Alox12/15 Deficiency Exacerbates, While Lipoxin A<sub>4</sub> Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.

Queck, Alexander; Fink, Annika F; Sirait-Fischer, Evelyn; Rüschenbaum, Sabrina; Thomas, Dominique; Snodgrass, Ryan G; Geisslinger, Gerd; Baba, Hideo A; Trebicka, Jonel; Zeuzem, Stefan; Weigert, Andreas; Lange, Christian M; Brüne, Bernhard

Alox12/15 Deficiency Exacerbates, While Lipoxin A₄ Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.

Queck, Alexander; Fink, Annika F; Sirait-Fischer, Evelyn; Rüschenbaum, Sabrina; Thomas, Dominique; Snodgrass, Ryan G; Geisslinger, Gerd; Baba, Hideo A; Trebicka, Jonel; Zeuzem, Stefan; Weigert, Andreas; Lange, Christian M; Brüne, Bernhard.

Afiliación

Queck A; Department of Internal Medicine 1, University Hospital, Goethe-University Frankfurt, Frankfurt, Germany.
Fink AF; Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany.
Sirait-Fischer E; Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany.
Rüschenbaum S; Department of Gastroenterology and Hepatology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Thomas D; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Frankfurt, Germany.
Snodgrass RG; Faculty of Medicine, Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany.
Geisslinger G; Institute of Clinical Pharmacology, Goethe-University Frankfurt, Frankfurt, Germany.
Baba HA; Branch Translational Medicine, Fraunhofer Institute for Molecular Biology and Applied Ecology, Frankfurt, Germany.
Trebicka J; Department of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Zeuzem S; Department of Internal Medicine 1, University Hospital, Goethe-University Frankfurt, Frankfurt, Germany.
Weigert A; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain.
Lange CM; Institute of Clinical Research, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Brüne B; Institute for Bioengineering of Catalonia, Barcelona, Spain.

Front Immunol ; 11: 1447, 2020.

Article en En | MEDLINE | ID: mdl-32760397

Asunto(s)

Araquidonato 12-Lipooxigenasa/genética; Araquidonato 15-Lipooxigenasa/genética; Hepatitis Alcohólica/metabolismo; Inflamación/metabolismo; Lipoxinas/metabolismo; Hígado/fisiología; Neutrófilos/inmunología; Animales; Modelos Animales de Enfermedad; Hepatitis Alcohólica/genética; Humanos; Inflamación/genética; Metabolismo de los Lípidos; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Activación Neutrófila/genética

Palabras clave

alcoholic hepatitis; arachidonate 12/15-lipoxygenase (Alox12/15); lipoxin A4; resolution of inflammation; specialized pro-resolving lipid mediators (SPMs)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Araquidonato 12-Lipooxigenasa / Araquidonato 15-Lipooxigenasa / Lipoxinas / Hepatitis Alcohólica / Inflamación / Hígado / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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