Switching antiepileptic drugs to once-daily dosing regimens in epilepsy patients.
Acta Neurol Scand
; 143(1): 51-55, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-32762074
ABSTRACT
BACKGROUND:
Antiepileptic drug (AED) non-adherence is an important factor contributing to poor seizure control in patients with epilepsy.AIM:
The aim of this study is to investigate seizure improvement after switching AEDs to once-daily dosing regimens in patients with drug-resistant epilepsy related to AED non-adherence.METHODS:
We performed a 10-year retrospective analysis of drug-resistant epilepsy patients whom AED non-adherence attributed to drug resistance and switched AEDs to once-daily dosing regimens. Successful switching was defined by at least 70% reduction in seizure frequency without troublesome adverse events.RESULTS:
Among 401 patients with drug-resistant epilepsy, 88 patients with AED non-adherence were switched to once-daily dosing regimens. Forty-six patients (52.3%) experienced successful seizure control following the switch. A higher chance of successful switch was found in patients without MRI abnormality (16/46 vs. 24/42; P = .04) and in patients who were switched to extended-release formulations or different AEDs with longer half-lives (33/46 vs. 19/42; P = .02).CONCLUSIONS:
Our study shows that switching AEDs to once-daily dosing regimens was an effective therapeutic option in patients with poor seizure control related to AED non-adherence. Treatment with extended-release formulations or drugs with longer half-lives should be considered in these patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cumplimiento de la Medicación
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Sustitución de Medicamentos
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Epilepsia Refractaria
/
Anticonvulsivantes
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Año:
2021
Tipo del documento:
Article