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Microbial RNAs Pressure Piezo1 to Respond.
Matute, Juan D; Duan, Jinzhi; Blumberg, Richard S.
Afiliación
  • Matute JD; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Duan J; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Blumberg RS; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rblumberg@bwh.harvard.edu.
Cell ; 182(3): 542-544, 2020 08 06.
Article en En | MEDLINE | ID: mdl-32763186
Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Microbioma Gastrointestinal Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Microbioma Gastrointestinal Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos