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Microbial RNAs Pressure Piezo1 to Respond.
Matute, Juan D; Duan, Jinzhi; Blumberg, Richard S.
Afiliación
  • Matute JD; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Neonatology and Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Duan J; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Blumberg RS; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rblumberg@bwh.harvard.edu.
Cell ; 182(3): 542-544, 2020 08 06.
Article en En | MEDLINE | ID: mdl-32763186
Serotonin production by enterochromaffin cells (ECs) is microbiota-dependent, but the mechanism of this is unknown. In this issue of Cell, Sugisawa et al. demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Microbioma Gastrointestinal Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Serotonina / Microbioma Gastrointestinal Idioma: En Revista: Cell Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos