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Advances in Chromatin and Chromosome Research: Perspectives from Multiple Fields.
Agbleke, Andrews Akwasi; Amitai, Assaf; Buenrostro, Jason D; Chakrabarti, Aditi; Chu, Lingluo; Hansen, Anders S; Koenig, Kristen M; Labade, Ajay S; Liu, Sirui; Nozaki, Tadasu; Ovchinnikov, Sergey; Seeber, Andrew; Shaban, Haitham A; Spille, Jan-Hendrik; Stephens, Andrew D; Su, Jun-Han; Wadduwage, Dushan.
Afiliación
  • Agbleke AA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA.
  • Amitai A; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Buenrostro JD; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Chakrabarti A; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Chu L; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Hansen AS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Koenig KM; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; JHDSF Program, Harvard University, Cambridge, MA 02138, USA.
  • Labade AS; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
  • Liu S; FAS Division of Science, Harvard University, Cambridge, MA 02138, USA.
  • Nozaki T; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Ovchinnikov S; JHDSF Program, Harvard University, Cambridge, MA 02138, USA; FAS Division of Science, Harvard University, Cambridge, MA 02138, USA.
  • Seeber A; JHDSF Program, Harvard University, Cambridge, MA 02138, USA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA. Electronic address: aseeber@fas.harvard.edu.
  • Shaban HA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA; Spectroscopy Department, Physics Division, National Research Centre, Dokki, 12622 Cairo, Egypt.
  • Spille JH; Department of Physics, University of Illinois at Chicago, Chicago, IL 60607, USA.
  • Stephens AD; Biology Department, University of Massachusetts, Amherst, Amherst, MA 01003, USA.
  • Su JH; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
  • Wadduwage D; JHDSF Program, Harvard University, Cambridge, MA 02138, USA; Center for Advanced Imaging, Harvard University, Cambridge, MA 02138, USA.
Mol Cell ; 79(6): 881-901, 2020 09 17.
Article en En | MEDLINE | ID: mdl-32768408
ABSTRACT
Nucleosomes package genomic DNA into chromatin. By regulating DNA access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most nuclear processes. In addition, dynamic organization of chromatin underlies both regulation of gene expression and evolution of chromosomes into individualized sister objects, which can segregate cleanly to different daughter cells at anaphase. This collaborative review shines a spotlight on technologies that will be crucial to interrogate key questions in chromatin and chromosome biology including state-of-the-art microscopy techniques, tools to physically manipulate chromatin, single-cell methods to measure chromatin accessibility, computational imaging with neural networks and analytical tools to interpret chromatin structure and dynamics. In addition, this review provides perspectives on how these tools can be applied to specific research fields such as genome stability and developmental biology and to test concepts such as phase separation of chromatin.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / Cromatina / Nucleosomas / Cromosomas Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / Cromatina / Nucleosomas / Cromosomas Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos