Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus.
Biochem J
; 477(16): 2967-2970, 2020 08 28.
Article
en En
| MEDLINE
| ID: mdl-32812643
ABSTRACT
Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aspergillus fumigatus
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Factores de Transcripción
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Proteínas Fúngicas
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Regulación Fúngica de la Expresión Génica
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Cobre
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Hierro
Idioma:
En
Revista:
Biochem J
Año:
2020
Tipo del documento:
Article
País de afiliación:
Austria